Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
Bicuspid Aortic Valve (BAV) is a highly heritable congenital heart defect.The low frequency of BAV Bag (1% of general population) limits our ability to perform genome-wide association studies.We present the application of four a priori SNP selection techniques, reducing the multiple-testing penalty by restricting analysis to SNPs relevant to BAV in